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Research in the Moulton Lab focuses on delineating the molecular mechanisms of genes associated with neurological disease, especially Alzheimer's disease. We utilize the genetic model organism, Drosophila melanogaster (fruit fly), to understand the consequences of disease-associated genetic variation. Using genetic technologies, human DNA sequences are swapped into the fly genome in place of the fly gene in order to probe the effects of specific variants on gene and organismal function (called h